OpenAI Applications Chief Fidji Simo Resigns Due to Illness, to Serve as Part-Time Adviser
Fidji Simo, CEO of OpenAI's Applications division, has resigned from her role after her medical leave extended beyond initial expectations. Simo, who first disclosed a neuroimmune condition in April, announced the decision in an internal letter and will transition to a part-time advisory role. OpenAI is expected to search for a successor.

Highlights
- Fidji Simo has resigned as CEO of OpenAI's Applications division after her neuroimmune-related medical leave extended beyond original expectations.
- Simo first disclosed her neuroimmune condition in April 2025 when she announced an extended leave of absence.
- Following her resignation, Simo will transition to a part-time advisory role at OpenAI.
- OpenAI is expected to conduct a search for a new CEO to lead its Applications division.
Fidji Simo, the CEO of OpenAI's Applications division, is stepping down from her executive role after her medical leave proved longer and more serious than originally anticipated, according to a report by The Wall Street Journal.
In an internal letter to staff, Simo explained that her condition had worsened beyond initial expectations, prompting her decision to resign as CEO of the Applications group. She will transition to a part-time advisory role with the company.
Simo first publicly disclosed in April that she had been diagnosed with a neuroimmune disease and would require an extended leave of absence. At the time, it was unclear how long her recovery would take.
With her departure now confirmed, OpenAI is expected to conduct a search for her successor to lead the Applications division.
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